Massachusetts Institute of Technology other research news

MIT researchers published results with a laboratory-created protein that contains two zinc fingers and the Oct-1 homeodomain. As reported in Science, computer modeling suggested the way to arrange the new protein's components with peptide linkers to achieve the desired targeting conformation.

When fused to an activation domain, the protein regulated promoter activity in vivo, in cells engineered with reporter genes. Stimulation of promoter action occurred in a dose-dependent manner. ...