Vertex preclinical data

VRTX has developed inhibitors of the ICE inflammatory pathway, which mouse models show should be effective without disrupting normal immune function.

As reported in Science, transgenic mice genetically defective for the ICE gene developed normally, even though their monocytes did not secrete either IL-1 alpha or beta after stimulation with lipopolysaccharide. Shutting down ICE produced no harmful effects, researchers said. ...