IntraBiotics preclinical data

IntraBiotics presented preclinical and in vitro data obtained with the Protegrin peptides that can kill microbes more rapidly than available antibiotics and do not appear to induce resistance in their pathogenic targets.

As reported at the Interscience Conference on Antimicrobial Agents and Chemotherapy, mice infected by intraperitoneal injection of various Staph and Enterococcus strains, including resistant ones, were injected immediately with Protegrin PG-1. Mortality was reduced over a seven-day period in a dose-dependent manner. Mice injected intravenously with resistant strains were also protected, even if PG-1 was delayed by an hour after infection. ...