University of Goteborg other research news

Swedish researchers reported that coupling myelin basic protein to a cholera toxin prevented experimentally induced autoimmune encephalitis in rats, a model for multiple sclerosis. Moreover, the oral treatment worked after induction of the disease, and reduced infiltration of leukocytes into the central nervous system.

As detailed in the Proceedings of the National Academy of Sciences, the cholera toxin serves to target the autoantigen myelin basic protein (MBP) to the gut-associated lymphoid tissue. MBP was chemically coupled to the non-toxic part of the toxin that binds to the lining of the gut. ...