University of Toronto et al. other research news

University researchers published in Nature the ability of a protein tyrosine kinase blocker, AG-490, to block leukemia cell growth in vitro and in vivo by inducing apoptosis, with no negative effects on normal hematopoiesis.

The growth of acute lymphoblastic leukemia (ALL) cells is known to depend on various cytokines, many of which induce tyrosine phosphorylation in lymphoid progenitor cells. As a result, attempts have been made to develop protein tyrosine kinase (PTK) blockers. ...