Middlesex Hospital other research news

Middlesex researchers reported in Nature that they have found that a mutation to the CLCN5 gene, which encodes a protein that functions as a renal chloride channel, may be responsible for three inherited kidney stone diseases: Dent's disease, X-linked recessive nephrolithiasis, and X-linked recessive hypophosphatemic rickets.

Kidney stones are familial in 45 percent of patients. The MIddlesex research indicates that the CLC5 protein may be implicated in other disorders associated with kidney stones ...