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European researchers reported that apoA-IV protects mice susceptible to atherosclerosis, even when fed a fatty diet. As published in Science, mice with the transgene for human apoA-IV, a cholesterol-carrying protein in the blood, have atherosclerotic lesions which are reduced in size.

The authors measured expression of apoA-IV in the liver of two different strains of mice bred with a susceptibility to atherosclerosis, then fed the mice either a normal diet or a fatty one. The transgenic mice in both groups showed a substantial reduction in the size of atherosclerotic lesions. Lesion size of the fatty streaks in blood vessels were reduced by 70 percent by the human ApoA-IV transgene at eight months of age. Moreover, protection was achieved by a mechanism that doesn't involve an increase in the concentration of high density lipoprotein (the so-called good cholesterol). ...