Sequana other research news

Researchers from SQNA and colleagues described in Nature a candidate gene for the mouse mutation tubby. In contrast to the rapid juvenile-onset weight gain seen in diabetic (db) and obese (ob) mice, obesity in tubby mice develops gradually, and strongly resembles the late-onset obesity seen in humans. Tubby mice become overweight despite eating a normal amount of food. They also suffer insulin resistance, retinal degeneration and neurosensory hearing loss. The tubby phenotype thus closely resembles certain human obesity syndromes.

Researchers described the identification of a single base error (T instead of G) in a candidate gene on chromosome 7. The error results in the retention of an intron, a stretch of DNA that doesn't specify a protein. ...