ARTICLE | Tools & Techniques

Precise base editing of mitochondrial DNA

A new RNA-free tool to edit the mitochondrial genome

July 10, 2020 2:08 AM UTC

David Liu and colleagues at the Broad Institute and University of Washington have achieved single-base editing of mitochondrial DNA for the first time, overcoming a limitation of CRISPR-based technologies and opening up new avenues for treating mitochondrial diseases.

Liu, a CRISPR veteran and base editing pioneer, is a co-founder of CRISPR and base editing companies Editas Medicine Inc. (NASDAQ:EDIT), Beam Therapeutics Inc. (NASDAQ:BEAM) and Prime Medicine LLC...