Metabolite scavengers to resensitize K-Ras-mutant colorectal cancer to Erbitux

INDICATION: Colorectal cancer

Scavengers of the glycolysis metabolite methylglyoxal could resensitize K-Ras-mutant colorectal cancer to Erbitux cetuximab. In patients, levels of methylglyoxal adducts were higher in tumors with K-Ras G12V mutations than tumors with wild-type K-Ras. In a human G12V K-Ras-mutant CRC cell line, the methylgloxal scavenger carnosine plus Erbitux reduced proliferation compared with either agent alone. The combination also inhibited tumor growth over either agent alone in three xenograft mouse models of colorectal cancer expressing the K-Ras G12V or G13D mutations...