OncoOne: targeting oxidized MIF for solid tumors

Led by Shire vets, the Austrian biotech is taking aim at a highly selective tumor antigen the biotech left behind

A trio of Shire veterans launched OncoOne on Wednesday with a €13 million series A round and a batch of biologics against oxidized MIF, a highly selective tumor antigen that was abandoned by the pharma when it shifted away from oncology R&D.

While the unmodified form of MIF, a well-known cytokine, is distributed throughout healthy tissues, the oxidized form is highly tumor cell-specific.

“During tumorigenesis,

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