A peptide fusion blocker for multiple coronaviruses, the cryo-EM structure of SARS-CoV-2 main protease, plus Locus, Excision and Harvard-Dana-Farber
BioCentury’s roundup of preclinical news
Fudan University develops pan-coronavirus inhibitor
A team led by Fudan University researchers has developed a lipopeptide-based pan-coronavirus inhibitor of viral membrane fusion. Described in a preprint on the bioRxiv server, the lipopeptide binds the SARS-CoV-2 and MERS-CoV spike proteins outside its receptor-binding domain, and prevents the spike