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Alzheimer’s prevention replays the same amyloid failures as the treatment setting

Lilly’s solanezumab, Roche’s gantenerumab miss DIAN-TU endpoint in presymptomatic AD patients

The Phase II/III DIAN-TU trial of Lilly’s solanezumab and Roche’s gantenerumab was always a long shot, given the previous late-stage failures of both agents in Alzheimer’s trials. Perhaps more surprising is that both compounds remain in development.

On Monday, Eli Lilly and Co. (NYSE:LLY) and Roche (SIX:ROG; OTCQX:RHHBY) announced that the anti-amyloid therapies solanezumab and gantenerumab each missed the primary endpoint of slowing cognitive decline in the investigator-led study, which

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