Grace: seeking cures in pathological roots
Grace Science hopes to parlay discovery of rare disease target into therapies for orphan, non-orphan diseases
Grace Science is targeting the root of a recently discovered genetic disorder for not just the ultra-rare condition but also for common diseases including cancer.
Grace Science LLC’s origins stem from the diagnosis of co-founder and CEO Matt Wilsey’s daughter Grace with NGLY1 deficiency in 2013.
The disease results from mutations reducing the activity of NGLY1, a deglycosylation enzyme that promotes proteasomal degradation. First proposed as a disorder in 2012, Wilsey said less than 60