Sangamo looks to next-gen therapies after reporting first version 'not enough'

Sangamo Therapeutics Inc. (NASDAQ:SGMO) reported interim data from two Phase I/II trials evaluating its in vivo genome editing zinc finger nuclease (ZFN) therapies SB-913 to treat mucopolysaccharidosis II (MPS II, Hunter syndrome) and SB-318 to treat MPS I (Hurler syndrome).

On a conference call Feb. 7 to discuss the data, President and CEO Sandy Macrae said that enzyme levels reported in the low- and mid-dose cohorts of the trials "is not enough" to provide clinical benefit...