ARTICLE | Translation in Brief

Storm’s RNA modification software

How Storm developed its open-source RNA modification algorithm

February 12, 2019 2:04 PM UTC

Storm Therapeutics Ltd. has created an algorithm to extend the use of mass spectrometric data to RNA epigenetics. Making it open source, the company plans to put the algorithm in as many hands as possible to yield new therapeutic targets.

In a December paper published on the preprint server bioRxiv, Storm scientists teamed up with bioinformatics scientists at University of Pennsylvania and University of Tübingen to describe an open-source algorithm known as NucleicAcidSearchEngine (NASE). This computational platform borrowed from the OpenMS platform used by mass spectrometry operators in the proteomics space and will boost the discovery power of RNA modification teams (see “Taking RNA Epigenetics by Storm”)...