ARTICLE | Emerging Company Profile

Spinogenix’s Spine Craft

Spinogenix is rebuilding dendritic spines, cognition in neurodegeneration

October 12, 2018 12:04 AM UTC

Spinogenix Inc. is developing small molecules for cognitive impairment in neurodegenerative diseases that rebuilds dendritic spines to reverse, not just halt, synaptic loss.

CNS synapses that relay signals involved in memory and cognitive function are formed between the axon of one neuron and the dendritic spines of the next. Synaptic loss and dendritic spine retraction correlate with cognitive impairment across neurodegenerative diseases. Neuronal architecture depends on how actin filaments interact and align themselves with other actin filaments, and some actin arrangements can prohibit or permit the outgrowth of dendritic spines...