Turning off the inflammasome

How inhibiting CMPK2 could block NLRP3-induced inflammasome activation

In a July Nature paper, a team from the University of California San Diego identified CMPK2 as a potential target for inflammatory diseases involving NLRP3 inflammasomes and may launch a spinout to develop the findings.

Inflammasomes are cytosolic multiprotein complexes that induce cytokine secretion and caspase-mediated cell death. The best characterized complex contains NLR

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