Turning off the inflammasome
How inhibiting CMPK2 could block NLRP3-induced inflammasome activation
In a July Nature paper, a team from the University of California San Diego identified CMPK2 as a potential target for inflammatory diseases involving NLRP3 inflammasomes and may launch a spinout to develop the findings.
Inflammasomes are cytosolic multiprotein complexes that induce cytokine secretion and caspase-mediated cell death. The best characterized complex contains NLR