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LRRK2 looming larger

University of Pittsburgh team links LRRK2 activity to idiopathic PD

Researchers from the University of Pittsburgh have identified a link between LRRK2 activity and idiopathic forms of Parkinson’s disease, further broadening the potential patient population for LRRK2 inhibitors in development, including two clinical compounds from Denali Therapeutics Inc. (NASDAQ: DNLI).

Multiple gain-of-function mutations in leucine-rich repeat kinase 2 (LRRK2) have been implicated in autosomal dominant forms of

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