BioCentury
ARTICLE | Translation in Brief

One-two punch for West Nile

How an intranasal siRNA therapy could treat and prevent recurrent West Nile virus

April 19, 2018 12:46 PM UTC

In a one-two punch, a group from Yale University and Hanyang University developed an intranasal therapy that treated West Nile viral infection and prevented its recurrence by promoting natural immunity in mice, effectively creating a vaccine substitute for an infection that has stymied clinical development of other prophylactics.

Study authors Priti Kumar, an associate professor of infectious diseases at Yale, and Sang-Kyung Lee, a professor in the department of biotechnology at Hanyang, co-founded Signet Biotech in 2016 to translate the work to humans...