ARTICLE | Preclinical News

Neural IL-4 repairs MS damage

March 1, 2018 10:15 PM UTC

In a paper published in Science Translational Medicine, scientists at Johannes Gutenberg University showed direct delivery of interleukin-4 (IL-4) to the CNS could treat multiple sclerosis (MS) by repairing axon damage without altering immune function.

Most marketed and clinical stage MS therapies target pro-inflammatory molecules to dampen the pathologic immune response. Few, if any, act directly on neurons to reverse axonal damage caused during a flare-up...