ARTICLE | Preclinical News
Improved dopamine receptor agonists for Parkinson’s
February 16, 2018 11:49 PM UTC
A study published in Nature Communications showed that non-catechol dopamine D1 receptor agonists reduced receptor desensitization, suggesting the compounds could help treat Parkinson's disease better than available dopamine replacement therapies.
Marketed D1 receptor selective agonists contain a catechol group, which desensitize the receptors and reduce treatment response after long-term exposure. Catechols also have poor CNS penetration, oral bioavailability and are quickly metabolized...
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