ARTICLE | Clinical News

TG reports updated Phase IIa MS data for anti-CD20 mAb

February 9, 2018 6:45 PM UTC

TG Therapeutics Inc. (NASDAQ:TGTX) reported updated data from a Phase IIa trial evaluating ublituximab (TG-1101, TGTX-1101) to treat relapsing multiple sclerosis. Ublituximab is a glycoengineered mAb against CD20.

Among 38 evaluable patients with relapsing MS, ublituximab reduced the mean number of T1 gadolinium-enhancing lesions to 0 at week 24 from 2.68 at baseline (p=0.0005). Among 40 evaluable patients, 97.5% of patients were relapse free at week 24. Ublituximab also led to 99% median B cell depletion at week four, which was maintained to week 24...

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TG Therapeutics Inc.