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Diabetes hits a checkpoint

Cranking up PD-L1 on HSPCs for autoimmune disease

A Science Translational Medicine study suggests increasing PD-L1 levels in hematopoietic stem and progenitor cells (HSPCs) could help treat Type I diabetes. Additionally, the authors think transplants of HSPCs modified with PD-L1-boosting gene therapies or compounds could be deployed to treat a wide range of autoimmune diseases, and the

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