Ghrelin’s LEAP forward
How LEAP2 could become a new target for metabolic diseases
NGM and MedImmune researchers have discovered a liver peptide, LEAP2, that is a natural antagonist of the metabolic target ghrelin. The peptide could serve as a new handle for either boosting or dampening ghrelin signaling to treat a variety of metabolic conditions ranging from diabetes and obesity to cachexia.
The results are the most recent fruit of a 2013 partnership between the MedImmune LLC unit of AstraZeneca plc (LSE:AZN; NYSE:AZN) and NGM Biopharmaceuticals Inc. to learn more