ARTICLE | Preclinical News

A faster method for harvesting HSCs for transplantation

December 9, 2017 12:08 AM UTC

Researchers report a new two-drug regimen could speed up harvesting of hematopoietic stem cells for transplantation and yield a population of cells that engraft more efficiently than those produced by standard regimens.

In a paper published in Cell, researchers at Massachusetts General Hospital, Indiana University and colleagues developed a new CXC chemokine receptor 2 (CXCR2; IL8RB) agonist by truncating its ligand, chemokine CXC motif ligand 2 (CXCL2; MIP2), and combined it with Mozobil plerixafor, a CXC chemokine receptor 4 (CXCR4; NPY3R) antagonist from Sanofi (Euronext:SAN; NYSE:SNY), which is already used for the application...