A window to Warburg

A study from Duke University suggests GAPDH inhibition could kill cancers that depend on the Warburg effect without upending normal cell metabolism. The authors homed in on the target via metabolic control analysis, and found biomarkers for susceptible tumors using metabolomics data.

Tumor cells often shift their metabolism to rely heavily on glycolysis instead of oxidative phosphorylation, a phenomenon known as the Warburg effect. But study author Jason Locasale, an assistant professor of pharmacology and cancer biology at Duke, told BioCentury the effect has been difficult to target because glycolysis is important in all cells...