ARTICLE | Preclinical News

RSPO1 restores gut biome in GvHD

October 27, 2017 11:23 PM UTC

Researchers at Hokkaido University (Sapporo, Japan) and colleagues found that R-Spondin 1 (RSPO1) stimulates differentiation of Paneth cells in the intestine, which secrete antimicrobial alpha defensins. The research, published in the Journal of Experimental Medicine, suggests a new method to restore the gut ecosystem that could help treat graft-versus-host disease (GvHD).

The team previously showed RSPO1 stimulated intestinal stem cell proliferation and reduced injury to the intestinal epithelium in a mouse model of bone marrow transplantation...

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R-Spondin 1(RSPO1)