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Transient nanotargeting

mRNA-loaded nanoparticles transiently modify therapeutic cells simply and safely

A team from the Fred Hutchinson Cancer Research Center has designed nanoparticles that introduce mRNA cargo to therapeutic cells in vitro, without requiring special instrumentation or causing the cell depletion or cytotoxicity that limits the utility of other transfection methods such as electroporation. The particles should enable easier and more cost-effective preparation of therapeutic CAR T and other cell therapies.

In an August Nature study, a team led by

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