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Medicines Co. to cut workforce, focus on inclisiran

October 25, 2017 10:24 PM UTC

In its 3Q17 earnings announcement, The Medicines Co. (NASDAQ:MDCO) said it would reduce headcount to fewer than 60 employees to focus on developing inclisiran (PCSK9si). Next week, the company plans to start a Phase III trial of the therapy to lower LDL-C; the company expects data in 2H19.

Inclisiran is a subcutaneous formulation of small interfering RNA against PCSK9. In August, Medicines Co. and partner Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY) reported data from the Phase II ORION-1 trial, which showed inclisiran reduced time-averaged LDL-C by 51% vs. placebo (p<0.0001) in patients with atherosclerotic cardiovascular disease (ASCVD) or ASCVD risk equivalents and elevated LDL-C (see BioCentury Extra, Nov. 15, 2016)...