ARTICLE | Product Development
Naked ambition
How miRagen designed its microRNA molecule for systemic delivery in cancer
October 21, 2017 12:35 AM UTC
Proof-of-concept data from miRagen Therapeutics Inc. show systemic delivery of its lead candidate can shrink lesions in cutaneous T cell lymphoma, and that its oligonucleotide platform can achieve broad distribution and a long half-life without the addition of a conjugate or vehicle.
On Oct. 13, miRagen reported interim data from a Phase I trial of MRG-106 to treat mycosis fungoides-type cutaneous T cell lymphoma (CTCL). All but one of the 23 patients treated showed improvement in total skin disease measured as the change from baseline in modified Severity Weighted Assessment Tool (mSWAT) score. mSWAT assesses skin disease over the entire body. ...
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