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SNPH picks between tumor proliferation and metastasis

October 19, 2017 8:56 PM UTC

A Wistar Institute team has shown syntaphilin (SNPH), known as a mitochondrial regulator in neurons, acts in cancer cells to mediate the decision of whether to proliferate or metastasize. While modulating the protein is a no-win situation, the discovery uncovers potential biomarkers and targets for metastatic disease.

Dario Altieri told BioCentury his team was not expecting to find a neuronal protein when it began screening for genes that regulated metastasis via mitochondrial bioenergetics. "About a year ago, there were no publications in PubMed about a role for SNPH in cancer," he said. ...

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