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Opening doors for I-O

Tumor lymphangiogenesis plus immunotherapy lets the right cells in

A Science Translational Medicine study has flipped the script for tumor lymphangiogenesis by turning VEGF-C, a hallmark of poor prognosis, into a biomarker and a target for successful responses to immunotherapies.

Tumors that are surrounded by a dense network of lymphatic vessels and express high levels of lymphangiogenesis-stimulating vascular endothelial growth factor C (VEGF-C) have been associated with metastasis and poor prognosis. Study author Manuel Fankhauser

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