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New light on gamma secretase failures in AD

In a study published in Cell Reports this week, researchers from Osaka University added another possible explanation for why gamma secretase/presenilin inhibitors have failed in Alzheimer’s disease trials.

The gamma secretase complex acts downstream of beta-site APP-cleaving enzyme (BACE) in the processing of amyloid precursor protein (APP) to generate beta amyloid, a toxic peptide that forms

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