Neurology

Mouse studies suggest inhibiting HCN2 could help treat pain in diabetic neuropathy. In a mouse model of diabetic neuropathy, the HCN channel inhibitor Corlanor ivabradine or nociceptive neuron-specific knockout of HCN2 decreased mechanical hyperalgesia compared with vehicle or normal HCN2 expression. Next steps could include identifying and testing HCN2 inhibitors in models of pain associated with diabetic neuropathy...