How pathogenic bacteria can escape copper toxicity
Two groups have uncovered distinct mechanisms by which bacteria escape copper toxicity, opening multiple avenues for targeting resistant pathogens.
Bacteria use copper to grow, but at high concentrations the metal becomes toxic. To maintain virulence, pathogens need to protect themselves against copper without shutting out the metal completely.
The first group, led by Jeffrey Henderson, published a study in Nature Chemical Biology in July identifying the bacterial siderophore yersiniabactin in overcoming copper stress. Henderson is an assistant professor