Stopping the invasion
How targeting the IRF3 pathway could prevent GBM recurrence
A team from the Netherlands Cancer Institute (NKI) has identified a network of extracellular matrix proteins that drives glioblastoma invasiveness and a master switch -- interferon regulatory factor 3 (IRF3) -- that can turn it off. The group believes combining IRF3 activation with standard of care could prevent recurrence.
In a Cell Reports study in July, the NKI team, led by Olaf van Tellingen and René