ARTICLE | Translation in Brief

Stopping the invasion

How targeting the IRF3 pathway could prevent GBM recurrence

August 17, 2017 9:00 PM UTC

A team from the Netherlands Cancer Institute (NKI) has identified a network of extracellular matrix proteins that drives glioblastoma invasiveness and a master switch -- interferon regulatory factor 3 (IRF3) -- that can turn it off. The group believes combining IRF3 activation with standard of care could prevent recurrence.

In a Cell Reports study in July, the NKI team, led by Olaf van Tellingen and René Bernards, developed a new in vitro model of glioblastoma multiforme (GBM) invasiveness and used it identify subpopulations of cells within patient-derived GBM cell lines that were more aggressively invasive than others. ...