ARTICLE | Tools & Techniques
Click bait
GSK is using click chemistry to validate how and where its compounds work
August 3, 2017 11:28 PM UTC
GlaxoSmithKline plc is developing click chemistry-based systems to pinpoint and quantify how drug candidates target DNA sequences, protein complexes and disease sites. The company believes the "click-probes" could slash failure rates in drug development by validating target engagement.
The idea is that click chemistry -- which covalently links chemical groups without disrupting nearby biochemical reactions -- can be exploited to catch and report molecular interactions in situ, providing a snapshot of where candidate drugs are binding and how that influences surrounding molecules...
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