Cycling across the membrane
How cell-permeable nanobodies enable access to intracellular proteins
In a Nature Chemistry study, a German team has shown that nanobodies coupled to cyclic peptides rich in arginine can target intracellular proteins with antibody-like precision and even deliver extracellular proteins to the cytosol.
Delivering proteins across the plasma membrane often relies on endocytosis, which means providing it with a means to escape the endosome before it is degraded. Cell-penetrating peptides like the HIV