Paper shows Tie2 inhibition decreases chemotherapy-induced metastasis

In a paper published in Science Translational Medicine, scientists showed that chemotherapy to treat breast cancer induces metastasis through a tumor microenvironment of metastasis (TMEM) mechanism, which has been used in the clinic to determine cancer invasiveness. The authors suggest inhibiting TMEM activity through blockade of tyrosine kinase receptor 2 (Tie2), which is expressed on TMEM-bound macrophages, may improve chemotherapy in a neoadjuvant setting or in metastatic disease.

The paper's authors include researchers from the Albert Einstein College of Medicine and Weill Cornell Medical College. ...