ARTICLE | Tools & Techniques

Clearing chemistry

A new use of click chemistry in vivo can trigger rapid drug clearance

June 15, 2017 9:22 PM UTC

A new study has discovered an in vivo use of click chemistry that can rapidly clear drugs from circulation in case of emergency. Although it raises the possibility of a universal safety switch, its adoption by industry could be limited by the need to individually vet each chemical reactant, plus the product they create.

While click chemistry is a well-established tool for non-toxic labeling of biological molecules in research labs, the method has started to gain traction in drug development as well. ...