Stapling β-catenin
FOG's stapled peptide could be the first β-catenin inhibitor to reach the clinic
Harvard University professor and serial entrepreneur Greg Verdine’s new start-up, FOG Pharmaceuticals Inc., is using his latest version of stapled peptide technology to block the notoriously undruggable protein, β-catenin, in metastatic colorectal cancer (mCRC).
Stapled peptides are cell-permeable peptides containing a chemical bridge (the staple) that stabilizes the core α-helix, enhancing the binding affinity of the helix and preventing proteolytic degradation. A key advantage is their ability to enter cells and block protein-protein interactions that are otherwise difficult to drug. ...
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