How a bone hormone could help treat obesity
Last week’s Nature publication of a hormone secreted by bone that suppresses appetite and can curb weight gain not only adds to the emerging picture of bone as a player in the endocrine system but establishes a bone-brain axis as a new way to treat obesity.
Osteoblasts - the cells that make bone - are now recognized as major players in bone biology, with the ability to both make and release hormones. They are thought to play a role in metabolism because they secrete osteocalcin, which promotes energy expenditure, insulin secretion and glucose homeostasis, and FGF23, which regulates phosphate metabolism in the kidney.
Principal investigator Stavroula Kousteni told BioCentury that while the role