ARTICLE | Tools & Techniques

A different horse in the race

How modified peptide nucleic acids could be new in vivo gene editing tools

November 10, 2016 11:03 PM UTC

The nucleases at the heart of gene editing systems such as CRISPR, TALENs and zinc finger nucleases (ZFNs) are key to the methods’ strength, forming a fundamental part of the blocking IP. A group at Yale University has developed an alternative technique based on peptide nucleic acids that requires no DNA-cutting enzyme and might have advantages over the other methods for in vivo applications.

While the enzymes differ between CRISPR, TALENs (transcription activator-like effector nucleases) and ZFNs, they are all responsible for one of the methods’ key vulnerabilities: the risk of cutting the DNA at incorrect locations. ...

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