ARTICLE | Distillery Therapeutics
Cancer
October 20, 2016 7:00 AM UTC
Cell culture and mouse studies suggesting inhibiting SET could help treat p53-mutant cancers. In a human p53-mutant bone cancer cell line, siRNA targeting SET decreased proliferation compared with scrambled siRNA. In a xenograft mouse model of p53-mutant colorectal cancer, shRNA targeting SET in the tumor decreased tumor growth compared with scrambled shRNA. Next steps could include testing SET inhibition in models of other p53-mutant cancer...
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