BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: MAP kinase 1 (MAPK1; ERK-2); BRAF

July 28, 2016 7:00 AM UTC

In vitro, cell culture and mouse studies identified a MAPK1 inhibitor that could help treat BRAF-mutant melanoma. Chemical synthesis and in vitro testing of pyrazolopyridinyl urea analogs identified a...