ARTICLE | Distillery Therapeutics

Therapeutics: Dermatophagoides pteronyssinus peptidase 1 (DERP1)

December 18, 2014 5:19 PM UTC

INDICATION: Allergy; asthmaIn vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma. Structural modeling and chemical synthesis identified a series of pyruvamide analogs that reversibly inhibited the peptidase activity of HDM allergen DERP1. In rats sensitized to HDM allergens, oral pretreatment with the lead compound led to decreased eosinophil levels in lungs following antigen challenge compared with vehicle. Next steps include further mechanistic and animal model studies to support clinical development.

TARGET/MARKER/PATHWAY: Dermatophagoides pteronyssinus peptidase 1 (DERP1)...