ARTICLE | Distillery Therapeutics

Therapeutics: Topoisomerase II binding protein 1 (TOPBP1)

December 18, 2014 4:25 PM UTC


Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer. In multiple human breast cancer cell lines, inhibition of TOPBP1 with the dye calcein AM decreased viability compared with vehicle. In a mouse xenograft model of breast cancer, calcein AM decreased tumor growth compared with vehicle. Next steps include conducting pharmacokinetics and safety studies of calcein AM in mice and screening for more potent TOPBP1 inhibitors. ...