ARTICLE | Clinical News
Tuning up CARs to target cancer cells
September 2, 2015 1:38 AM UTC
A preclinical study EGFR compared to with high-affinity CAR therapy to treat glioblastoma in mice.
EGFR is overexpressed in glioblastoma and the study's authors hypothesized that a CAR with low affinity for the target would not bind to low-density EGFR found in normal tissues. ...