ARTICLE | Clinical News

Sirtris researchers publish SIRT1 data

August 13, 2010 11:10 PM UTC

Researchers at Sirtris Pharmaceuticals Inc., a subsidiary of GlaxoSmithKline plc (LSE:GSK; NYSE:GSK), reported kinetic and biophysical data for 26 of its sirtuin 1 ( SIRT1)-activating compounds. The data suggest that the compounds interact directly with SIRT1 and activate SIRT1-catalyzed deacetylation through an allosteric mechanism without the need for a fluorophore tag on the substrate. Data were published in the Journal of Biological Chemistry. ...